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Discussion and conclusions The most common side effects of low dose MTX include fatigue, nausea, abdominal discomfort, diarrhea, stomatitis, and rash, which are usually reported in the ambulatory setting [3]

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This article examines the side effect profile of B12 therapy in older adults, covering common reactions such as injection site discomfort and gastrointestinal symptoms, rare serious adverse events requiring urgent medical attention, important drug interactions with medications like proton pump inhibitors and metformin, and evidence-based dosing guidance aligned with NICE and BNF recommendations for safe, effective B12 replacement in this vulnerable population