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We are proposing to amend 412.103(d)(1) and to add new paragraph 412.103(d)(3) to provide that, subject to the hospital meeting the requirements set forth at proposed 412.92(b)(2)(vi), the effective date for rural reclassification for such hospital would be as of the effective date determined under 412.92(b)(2)(vi)

6 Conclusion 6.1 Current status and future prospects of antioxidant therapy in periodontitis Current research shows that antioxidant therapy has significant potential in the management of periodontitis

CYP1, CYP2, CYP3, CYP4 and CYP7 are believed to play crucial roles in hepatic as well as extra-hepatic metabolism and elimination of xenobiotics [50], [58], [84]

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