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Excessive and chronic alcohol use can alter brain chemistry, resulting in alcohol cravings, dependency, and ultimately, addiction to alcohol

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For grade 2 toxicities, we may consider holding treatment, and then resuming when symptoms or lab values improve to normal or to grade 1, or we may consider low-dose steroids like 0.5 to 1 mg/kg per day of prednisone for grade 2. For grade 1, asymptomatic or minimally symptomatic irAEs, or where findings are confined to a radiographic or laboratory change, supportive care and/or localized therapy on an outpatient basis, continuation of the ICI at full dose, and increased frequency of monitoring are recommended