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The risk of severe GI events is increased by the presence of the following factors: history of peptic ulcer disease or GI bleed, smoking, alcohol usage, concomitant usage of anticoagulants, or oral corticosteroids, older age, and poor general health status

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however, standardized extracts with defined polyphenol content are necessary for reproducible clinical outcomes

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(European Food Safety Authority, 2006)

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Plasmids encoding the proteins to be expressed were transfected into protoplasts using the plasmid-PEG-calcium transfection method(3, 4)

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