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In PD, nNOS expression is upregulated in the substantia nigra (Eve et al., 1998), whereas microglial iNOS levels are elevated across multiple neurodegenerative disorders (Lowenstein and Padalko, 2004)

First, PK/PD tractability should be decisive, favoring OSCs with reproducible human or large-animal exposure biomarkers or stable synthetic derivatives

Customizing a treatment plan takes careful deliberation

And, as commenters pointed out in response to our proposals in the CY 2015 OPPS/ASC proposed rule, in some states, external data sources may not contain data sufficient for requesting hospitals to make the comparisons required under the statute and our existing regulations because those states do not require all hospitals to report their Medicaid inpatient admission data (79 FR 66991)

Negri et al., 2021)