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When cagrilintide is paired with semaglutide as CagriSema, the gap narrows23% for CagriSema versus 25.5% for Zepbound in a direct head-to-head trialbut Zepbound still holds a modest edge

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Compared with males taking the placebo, after 36 months of treatment, males taking Prolia had BMD that was increased by: 7.9% in their spine 5.7% higher in their hip 4.9% higher in their femoral neck (the upper part of the thigh bone that connects into the hip) In addition, Prolia also decreased the risk of spinal fractures in males taking ADT

But most reactions are mild to moderate, typically resolving within 24-48 hours