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These effects were achieved through the regulation of the Akt/mTOR/GSK-3 signaling pathway, positioning ESP as a promising therapeutic agent for addressing cognitive decline associated with AD (Luo et al., 2022)

The transamination reaction depends heavily on the conversion of pyridoxine, also known as pyridoxol and gravidox, to pyridoxal phosphate (PLP)

One more possibility to customize the reaction of individuals to the natural products is personalized nutrition and precision-medicine approaches, which consist of genetic, metabolic, and microbiome factors

124,125 In a randomized placebo-controlled trial in 52 participants with menopausal symptoms, 30 mg vitex extract twice daily for eight weeks reduced hot flashes, anxiety, and total menopausal symptom scores