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Antagonists of G-protein-coupled receptor family C group 6 subtype A (GPRC6A) abolished the additive effect of ornithine on preference for MSG solutions in both behavioral and electrophysiological experiments, suggesting that ornithine is a kokumi substance that binds to another possible kokumi receptor, GPRC6A

Greenamyre et al., 2010)

Hyperinsulinemia, which accompanies insulin resistance, along with early low-grade inflammatory signals, can further stimulate the expression and activation of NADPH oxidase (particularly the NOx subtype) on the cell membrane

& Aniya, Y

Excess intracellular iron catalyzes Fenton reactions, generating reactive oxygen species (ROS) that oxidize polyunsaturated fatty acids (PUFAs) in membranes [88], resulting in membrane rupture and cell death (Fig

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