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Zhang et al., 2015

Decreased GSH concentrations were noted in patients with alcoholic (2.55 0.1 mol/g of liver) and nonalcoholic liver diseases (2.77 0.1 mol/g of liver) compared with controls (4.14 0.1 mol/g of liver) that were speculated to be a contributing factor in liver injury and could enhance the risk of hepatic toxicity from a variety of toxic agents

In addition, the COP1-SPA complex associates with CULLIN4, and the CUL4 COP1-SPA promotes degradation of the positively acting transcription factors in the dark to repress photomorphogenesis 22

4.3 Multiple sclerosis Multiple sclerosis (MS) occurs as an autoimmune response to autoantigens mediated by autoreactive T cells secondary to environmentally triggered genetically susceptible hosts (80)