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But in modern life, it rarely switches off, leaving your nervous system running on high long after the day is done

Mitophagy defects have been found in neurodegenerative diseases such as Hungtingtons disease, Alzheimers disease and Parkinsons disease (Schapira and Gegg, In the newborn female SE offspring, mitochondrial fission was reduced, however markers of fusion and the autophagosome were increased, which may preserve the function of mitochondria

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10.1155/2020/9039843 76 WuL.LiuG.WangW.LiuR.LiaoL.ChengN.et al (2020)

JMJD3 and NF-B-dependent activation of Notch1 gene is required for keratinocyte migration during skin wound healing