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Enhanced serotonergic neurotransmission has been discussed to mediate better mood and sleep in human patients with depression, for example after the intake of selective serotonin-reuptake inhibitors (SSRIs) 34,35 , however see ref

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While refrigeration can't stop this, the overall slowdown of chemical reactions helps mitigate the damage

Current critical care management of TBI focuses on general intensive care support and specific neurocritical care interventions to minimize further damage to the brain by preventing hypoxia, hypotension and hypoventilation