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Selective and membrane-permeable small-molecule NNMT inhibitors reverse high-fat dietinduced obesity in mice

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These include 1) congenital pernicious anaemia, where there is a genetic defect in IF synthesis, leading to B12 malabsorption, 2) Imerslund-Grsbeck Syndrome (IGS) caused by mutations in genes encoding cubulin and amnionless , 3) inherited HC or TCII deficiencies, and 4) intracellular cobalamin defects (CblA-CblG defects)

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By aiding in the conversion of food into energy, B12 provides sustained vitality throughout the day