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At the organ level, MFs can influence larger brain networks, which play a critical role in coordinating functions such as motor control, cognition, and emotion (Lu et al., 2024

The intrinsically disordered interdomain region between the helicase and nuclease domains of an archaeal Hef protein from Thermococcus kodakarensis was shown to be involved in interactions with multiple proteins including PCNA1 and a RecJ-like protein, suggesting that Hef acts as a scaffold and uses this IDR for sequential interaction with several proteins to control the repair pathway at the stalled fork (Ishino et al., 2014)

Vitamin B12 deficiency often occurs when the body does not get enough B12

ARA-290 operates through three complementary mechanisms identified across pre-clinical and clinical research: 1

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