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Such an imbalance is responsible for severe damage to essential biomolecules, such as lipids (lipid peroxidation), proteins (oxidation and inactivation), and DNA (strand breakage and mutations), which is associated with the pathogenesis of numerous diseases, including cancer, neurodegenerative diseases, cardiovascular diseases, and the aging process [28]

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However, several factors support its safety profile

Across multiple experimental settings, these agents demonstrate biologic activity involving angiogenesis, inflammatory modulation, fibroblast migration, and collagen remodeling

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Chronic use is associated with tolerance, withdrawal, and memory disturbances