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Limitations in the present study include statistical power

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Blood 126 (23), 3059

Pruritus characteristic of cirrhosis predominantly manifests as a central phenomenon, purportedly stemming from augmented release of -endorphin, Met-enkephalin, and endomorphin-1,2, which stimulate -receptors within nerve tissues

Studies have shown that activation of the Wnt pathway is associated with the development of ACM ( 2.3.2 NLRP3 inflammasome pathway The NLRP3 inflammasome is a critical component of the immune response, capable of detecting intracellular pathogens and damage signals ( 2.3.3 Nrf2 pathway ACM is a pathological condition characterized by alterations in atrial structure and function, frequently associated with AF and heart failure (HF) ( 2.3.4 Key molecules and their roles Several key molecules play important roles in the cellular and molecular mechanisms of ACM that affect atrial structure and function