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[DOI] [PMC free article] [PubMed] [Google Scholar] 87.Lei X.G., Cheng W.H., McClung J.P

niloticus (Yu et al., 2022)

Using structure-based analyses and cell models, including patient fibroblasts, of this variant, we found that the missense variant destabilized a critical loop, which disrupted the active site and caused a substantial loss of enzymatic function

Topical serums work at the skin surface and in the uppermost layers of the dermis, which means they address pigmentation locally rather than systemically