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5d illustrates that the positive control group exhibited a significantly higher fivefold increase in MYOC gene expression when compared to the negative control group

Immunohistochemistry revealed that NRTP significantly increased nuclear p-FOXO3A in ovarian PMFs in the M group

Consistent with decreased RNR activity, treatment of Control cells with nutlin-3 or MI-773 decreased levels of dAMP, a metabolite downstream of RNR (Fig 3E)