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If a trial is recommended, do it under specialist oversight with low dose and close follow-up

Even though DOX cannot cross the bloodbrain barrier (BBB), it can cause substantial neurotoxicity with neuronal and synaptic loss, prompting cognitive deficits in the brain [39, 42] In the current work, DOX-induced oxidative stress was proved by higher levels of NOX4 and MDA, accompanied by loss of antioxidant defense mechanisms shown as lower GSH and SOD activities

Gorczyca, W., Gong, J

The acellular fraction of BALF was obtained through double centrifugation, and the supernatant was used for further analysis

[DOI] [PubMed] [Google Scholar] 59.Ewald N., Kaufmann C., Raspe A., Kloer H

Suppressive effect of autocrine FGF21 on autophagy-deficient hepatic tumorigenesis