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Room temperature storage accelerates degradation significantly

2014 follow-up study was retracted in 2025, which means the foundational evidence base has significant integrity concerns that should be weighed carefully

Study Identification and Selection Approach The initial search yielded a large body of literature across peptide agents and clinical domains

J Physiol (Paris) 1999

These users describe skin quality remaining noticeably superior to pre-treatment baseline even year post-discontinuation, with specific improvements including reduced fine lines maintaining 50-70% of treatment peak reduction, improved skin firmness and elasticity sustaining 40-60% of maximum improvement, better overall texture and appearance persisting at 50-80% of treatment levels, and completely resolved specific issues like scarring or hyperpigmentation staying improved

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