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A plant-based mutant huntingtin model-driven discovery of impaired expression of GTPCH and DHFR

Choi M, Schneeberger M, Fan W, Bugde A, Gautron L, Vale K, Hammer RE, Zhang Y, Friedman JM, Mangelsdorf DJ, Kliewer SA (2023) FGF21 counteracts alcohol intoxication by activating the noradrenergic nervous system

The dihexa half life ensures plasma concentrations fall to negligible levels within six to eight hours, meaning every-other-day dosing creates 40+ hour gaps with zero receptor engagement

It is like having too many fire extinguishers

Many drinks, especially mixed drinks, contain more than 1 standard drink worth of alcohol

Malariology: malaria parasites and other haemosporidia