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The main mechanism responsible for the observed permanent distal sensory loss is associated with the death of sensory neurons (i.e., nerve cell necrosis) due to the binding of oxaliplatin to mitochondrial DNA [36]

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GPX4 volume density is increased from 0.0018 0.0002 in controls (n = 11) to 0.0038 0.0007 in PD (n = 12) (P = 0.0192), indicating that GPX4 is either upregulated in surviving neurons or that a greater percentage of cells not expressing GPX4 are lost compared to cells with GPX4

Immunoblot analysis Samples were collected at 4 h intervals from 1520 whole heads obtained from CS flies and processed as described [29]

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Because his Borrelia burgdorferi IgG titers were markedly elevated and he had a history of tick bites and rash, a lumbar puncture was performed