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At lower content of selenium, the ratio of GSH to GSSG did not increase significantly, probably due to the adaptive increase in GSH, which was an attempt to maintain the normal level of GSH to GSSG in the yeast cellular cytosol

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As a result, strong empirical evidence during the preclinical phase is required

Unfortunately, definitive and more direct evidence implicating dopamine in the etiology of bipolar disorder is still unavailable

Nat Genet 2024;56:2392-406

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