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In a cohort study, individuals who progressed to Alzheimers showed elevated 3-HAA, higher 3-HAA/anthranilic acid ratio, increased 3-HK, and reduced PA, suggesting these KP changes could serve as early biomarkers of cognitive decline [249]

Upregulation of these five genes was associated with poor prognosis

[13] Animal models [edit] Knockout mice of GPX4 die at embryonic day 8 [14] [15] and conditional inducible deletion in adult mice (neurons) results in degeneration and death in less than a month