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Organic Blueberry, Broccoli, and Rosehips provide a rich source of antioxidants to combat free radical damage and support overall wellness

doi: 10.1111/j.1471-4159.2004.02373.x

Nrf2 confers resistance to metal ion-dependent cell death through transactivation of downstream target genes as outlined in Figure 5, making targeted inhibition of NRF2 to simultaneously induce ferroptosis and cuproptosis in cancer cells a potential new strategy for HNSCC treatment

These results were consistent with the reports showing that M1 macrophages were protected from ROS-induced DNA damage as a result of increased expression of multiple antioxidant genes, such as superoxide dismutase 2 (SOD2) [95, 96]

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Its protein structure takes the form of a tetramer composed of a complex of 4 identical subunits, each containing 527 amino acid residues and a heme group with Fe 3 + [22, 23]