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Figure 2 Several studies in recent years have shown that silencing TRFC (the gene encoding TFR1) inhibits erastin-induced iron apoptosis and prevents LIP accumulation, whereas the heme oxygenase HO-1 increases intracellular free iron levels and promotes heme degradation, which speeds up the ferroptosis process (78, 79)

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To view a copy of this licence, visit About this article Cite this article Ahmed, A.M.A., Osman, S.A

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10.1016/j.biomaterials.2011.03.056 320 YinJ.LiuM.RenW.DuanJ.YangG.ZhaoY.et al (2015)