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Unusual foam or bubbles during reconstitution can signal degradation products that affect surface tension

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Importantly, a decrease in ECM remodeling via MMP activity and subsequent increase in fibrosis is correlated with aging 104

Alternatively, the otic gel formulation is applied via syringe and needle, wherein the needle is inserted through the tympanic membrane and guided to the area of the round window or crista fenestrae cochleae

Though it was previously thought that EPO was solely a key gene in the maturation and proliferation of red lineage progenitors, later studies showed that it is widely expressed in mammalian brain cells, including neurons and glial cells, which also express EPO receptors (37)