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Hofmans STV, Berghe L, Devisscher B, Hassannia S, Lyssens J, Joossens P, Van Der Veken P, Vandenabeele K, Augustyns

Hum Gene Ther 2023;34:92746

For vitamin D insufficiency (2129 ng/mL), the dosing is 8000 IU daily for 4 weeks followed by an identical maintenance regimen (221)

The tortuous path of lactate shuttle discovery: From cinders and boards to the lab and ICU

PLoS ONE 8:e60733

However, successful clinical translation requires rigorous validation of molecular targets, optimization of pharmacokinetics, and comprehensive evaluation of long-term safety