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2.1 Literature screening and selection Two authors independently screened titles and abstracts for relevance, followed by a full-text review of eligible articles

In AS mouse models, sterile inflammation is also shown to drive cytokine production, and neutrophils, once activated, initiate effector functions and release NETs (120) showed that chloromethyl ketone inhibited PAD4, thereby reducing the formation of NETs and the lesion area of atherosclerotic plaques, further suggesting the important role of NETs in AS

In brief, these clinical investigations demonstrated that gut microbiota may serve as predictor for the onset and progression of DN

Jara M, Norlin J, Skalshi Kjr M, Almholt K, Bendtsen KM, Bugianesi E, Cusi K, Galsgaard ED, Geybels M, Gluud LL, Harder LM, Loomba R, Mazzoni G, Newsome PN, Nitze LN, Palle MS, Ratziu V, Sejling A, Wong V, Anstee QM, Knudsen LB

Knocking out Nrf2 or using HO-1 antagonist reversed DOX-induced heart injury and death in mice, indicating that free iron released by heme degradation is a prerequisite for inducing heart injury

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