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Prof Alessandro Prete, senior author of the study, said: "These findings should prompt us to think more carefully about which patients need closer follow-up, and whether active treatment to reduce cortisol excess including surgery in selected cases could protect their long-term cardiovascular health." Read more: #Endocrinology #CardiovascularHealth #MetabolicHealth #HealthResearch To view or add a comment, sign in Question for endocrinologists and neuroendocrinologists: Can severe purulent bacterial meningitis, particularly pneumococcal meningitis, cause delayed hypothalamic-pituitary dysfunction years after recovery

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During this process, dsRNA as a direct and potent ligand for NLRP6 promotes the LLPS of oligomerized NLRP6, leading to the formation of condensation, which increases the local concentration of the pyrin domain (PYD), facilitating filamentous PYD-PYD interactions that recruit ASC