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J Biol Chem 277:11581165 Fraser JA, Kansagra P, Kotecki C, Saunders RD, McLellan LI (2003) The modifier subunit of Drosophila glutamate-cysteine ligase regulates catalytic activity by covalent and noncovalent interactions and influences glutathione homeostasis in vivo

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Although several natural compounds have entered preclinical or early clinical trials, the transition from bench to bedside is often hindered by limited pharmacokinetic stability, unclear mechanisms of action, and heterogeneous patient responses

403 Antibodydrug conjugates Antibodydrug conjugates represent a novel class of targeted therapeutics characterized by large molecular carriers comprising antibodies, cytotoxic small molecules, and linking chains