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Principal Investigator, Linus Pauling Institute Professor, Dept

Accelerated pericyte degeneration and bloodbrain barrier breakdown in apolipoprotein E4 carriers with Alzheimers disease

Specifically, ROS levels in the MEM, AMP, and CAZ treatment groups decreased to 201 9, 148 7, and 125 3%, respectively (Figure 5B)

Complexes I and III of the mitochondrial electron transport chain, which transforms 13 percent of total oxygen into the superoxide anion, is the primary source of O2in a cell (102)

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Results: rAAV8-mediated knockdown of Capn4 mediated a robust and stable suppression of hepatic Capns1 expression, coupled with a nearly complete abrogation of detectable Capn1/2 enzyme activity