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( After consideration of public comments as discussed in section V.C

The liposomes loaded with Pde3b siRNA polarized macrophage to M2 by enhancing PKA-CREB-C/EBP pathway, reduced inflammatory response, suppressed synoviocyte infiltration, and alleviated bone and cartilage erosion (131)

(Lykov et al., 2020) implanted Wistar rats BMSCs with/without erythropoietin (EPO) into the IDD mouse model

It has demonstrated effective anti-cancer activity, targeting multiple pathways to inhibit tumor growth and showing strong inhibitory effects against many malignancies, including pancreatic, breast, and nasopharyngeal cancers (262264)