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These data indicate that the overall magnitude of brain injury induced by the TBI procedure, measured as BBB disruption, was comparable for each group of mice and moreover, preinjury supplementation with Immunocal had no discernible protective effect against the primary mechanical injury induced by a moderate TBI

10.1016/j.nbd.2016.07.007 Neurobiol

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However, of all the medications examined, metformin was most strongly statistically, significantly correlated with reduced plasma magnesium concentration