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Nature 554 , 475480 (2018)

Naqvi SM, Gansau J, Gibbons D, Buckley CT

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You should contact your GP if: Your B12 level is significantly elevated (markedly above your local laboratory's reference range) without obvious explanation such as supplementation You have persistent elevation on repeat testing You experience unexplained symptoms such as unintentional weight loss, persistent fatigue, night sweats, fever, or abdominal discomfort You notice unusual bruising, bleeding, or enlarged lymph nodes You have jaundice (yellowing of skin or eyes) or other signs of liver disease You have a history of liver disease, kidney disease, or blood disorders Immediate medical attention (contact NHS 111 or attend A&E) is warranted if you experience severe symptoms such as significant bleeding, severe abdominal pain, confusion, or signs of acute illness, though these would rarely be directly related to elevated B12 itself

It causes the body to heat up, which, combined with hours of dancing in a warm environment, can cause the bodily temperature to reach lethal levels

Treatment may also be based on the patients symptoms, occupation, activity level, health, and age