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Some limitations of antibodies for clinical use are slow diffusion into tumor tissue, limited in vivo stability, and high production costs [7, 11, 12]

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2.5.2 LCMS/MS data-dependent acquisition Digested samples were analyzed by nano HPLC using an EASY-nLC 1,000 chromatograph coupled to a Q-Exactive HF mass spectrometer (Thermo Fisher Scientific, Pittsburgh, PA, United States), using an EASY-Spray Accucore (P/N ES801) Thermo Scientific reverse phase column coupled to an EASY-SPRAY Electro Spray ionizer (Thermo Fisher Scientific, Pittsburgh, PA, United States), with Spray voltage between 2.53.5 kV

Mechanisms of CVD and CKD in patients with diabetes Vascular damages of ASCVD in patients with diabetes are characterized by endothelial and vascular smooth muscle cell dysfunction [12]