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Excessive ROS, particularly superoxide and hydrogen peroxide, is present in the kidneys of animal models of hypertension and may contribute to the development of hypertension through several mechanisms, such as decreasing NO bioavailability 46,65

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Overexpression of glyoxalase-I in bovine endothelial cells inhibits intracellular advanced glycation endproduct formation and prevents hyperglycemia-induced increases in macromolecular endocytosis

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doi: 10.1016/j.diagmicrobio.2016.06.015 [DOI] [PMC free article] [PubMed] [Google Scholar] Sundnes KO, and Haimanot AT (1993)