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Casalboni, F

Glutathione deficiency leads to an increase in oxidative stress, accumulation of toxins and heavy metals

When it came time to vote, Judith Kramer, a physician and professor of medicine at Duke University, reminded her fellow panelists of the opportunity before them, noting that attempts to make acetaminophen safer had foundered for decades

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The analysis also highlighted downregulation in antioxidant and stress response pathways, such as reduced glutathione, along with changes in phenylalanine metabolism (e.g., 2,3-dihydro-2,3-dihydroxybenzoate), signaling pathways (e.g., tyrosine and arginine), carbohydrate metabolism (e.g., fructose 1-phosphate and allose), and nucleotide and nucleic acid metabolism (e.g., adenine and UDP)