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Crossover trials, active-controlled trials, and other approaches have been used to mitigate this issue, though these options may not always be suitable for study, and have received their own criticism

Active Ingredient Content *NRV: Nutrient Reference Value for adults

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doi: 10.1186/s12943-021-01316-8 2 LyuHBaoSCaiLWangMLiuYSunYet al

Repeated administration of dapirolizumab pegol in a randomised phase I study is well tolerated and accompanied by improvements in several composite measures of systemic lupus erythematosus disease activity and changes in whole blood transcriptomic profiles

Additionally, both the molecular docking assay and the FXR-knockout assay demonstrated that Rc could activate the FXR signaling pathway, resulting in the inhibition of NF-B and subsequently reducing inflammation [253]