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Ambroxol as a disease-modifying treatment to reduce the risk of cognitive impairment in GBA-associated Parkinsons disease: a multicentre, randomised, double-blind, placebo-controlled, phase II trial

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SOD1 is an enzyme that catalyzes the dismutation of superoxide radicals into hydrogen peroxide and oxygen, providing a crucial antioxidant defense

USP29 deubiquitinates and stabilizes oncogenic MYC (including c-MYC and N-MYC), which directly activates the transcription of multiple genes involved in glutamine metabolism, including glutamate dehydrogenase 1(GLUD1), glutamic-oxaloacetic transaminase 2 (GOT2) and glutamicpyruvic transaminase1/2 (GPT1/GPT2)