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[6] Coordinated regulation of gluconeogenesis and glycolysis If glycolysis and gluconeogenesis were simultaneously active at high rates within the same cell, the net result would be the consumption of ATP and the generation of heat , particularly at the irreversible steps of both pathways, with no productive metabolic outcome

Nature 617 , 395402 (2023)

In patients with porphyria the haem is produced, but precursors in the pathway may accumulate and cause symptoms

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