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Mood changes such as irritability or feeling low are also common, as well as tingling sensations in the hands and feet that signal nerve involvement

Future medicinal chemistry efforts may yield next-generation compounds with enhanced properties, including improved tissue selectivity, modified pharmacokinetics, or additional mechanistic activities that complement NNMT inhibition

Twelve years, several rounds of animal results, and the count of published human efficacy trials sits at zero

The problem with recommending patients consume more of these B-12-containing foods is that these animal proteins and processed foods, except fish, are the ones that we want to decrease since they lead to increased inflammation, increased cholesterol and worsening of asthma and allergies.

10.1371/journal.pone.0130908 111 QiuY.XuS.ChenX.WuX.ZhouZ.ZhangJ.et al (2023)