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However, progein was identified to be the critical target of farnesyltransferase inhibitors (FTIs) (Yang et al., 2010) and one FTI called lonafarnib have been tested in a cohort study which showed a significantly lower mortality rate (hazard ratio, 0.12) after a median of 2.2 years of follow-up ( The investigation of the GPX4 function was far ahead of the emergence of ferroptosis

In addition to surgery, germ cell tumors are further managed with chemotherapy involving cisplatin, bleomycin, and either vinblastine or etoposide (25, 26)

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