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Subsequently, cells were subjected to a defined chase period (e.g., 12 hours) in serum-free medium lacking ITalk, following an established protocol for secretome analysis 22

In addition to being one of the most bioavailable forms of carnitine, l-carnitine fumarate provides fumaric acid, leading to a synergistic effect in cellular energy production in the mitochondria.

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This targeted delivery aims to maximize therapeutic effects by delivering both drugs to the affected psoriatic skin layers, potentially offering a more effective treatment strategy (116)

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