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Shirai et al., 2025

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During the follow-up, GH and IGFBP1 levels continuously rose and were higher or equal to that of CON, respectively, at 52 weeks (Fig

doi: 10.3892/ijo.2016.3360 125 AlmendroVAmetllerEGarca-RecioSCollazoOCasasIAugJMet al

See Example Case 3 the individual did not improve using the commonly known intermediates and support supplements of the methionine cycle such as B12 (cyanocobalamin) by injection, folic acid, betaine, SAMe, N-acetylcysteine, and even glutathione in the neat form (not in the form claimed in the present invention)

Meanwhile, this also demonstrates that the mechanism of action of TCM is not limited to the direct antagonistic effects on disease foci, but also encompasses cross-organ, trans-system, and remote indirect regulatory effects mediated through the modulation of intermediary substances such as GM metabolites