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Moreover, as the catalytic pockets of tyrosinases have been reported to exceedingly conserved across the diverse species 5 and mammalian tyrosinase crystal structure is not available yet, homology model of human tyrosinase (UniProtKB-P14679) was collected from AlphaFold database ( 39 and aligned with the 3D crystallographic structure of mushroom tyrosinase (mh-Tyr) using Superimpose tool in the Maestro v12.6 tool of Schrdinger suite-2020.4 40

Hereditary parkinsonism with dementia is caused by mutations in ATP13A2, encoding a lysosomal type 5 P-type ATPase

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The systemic metabolic improvement supports fat reduction throughout the body, including resistant areas like abdominal and thigh regions

AB: Alcian blue

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