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A42 levels and the A42/A40 ratio were reduced, but polymerization of A40 and A42 increased, along with enhanced resistance to proteolytic degradation by neprilysin (Nilsberth et al., 2001

Lancet Oncol 23:6576 Mikhael J, Belhadj-Merzoug K, Hulin C (2021) A phase 2 study of isatuximab monotherapy in patients with multiple myeloma who are refractory to daratumumab