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Optic nerve atrophy was a variably occurring symptom [41, 66, 73]

After reperfusion, elevated oxidative stress and mitochondria damage lead to increased cell death across various mechanisms

The animals were incubated with 1 l MitoSOX (final concentration 10 M) in a rocker at 20C in the dark for 24 hours

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Activation of PDHK1 inhibits pyruvate dehydrogenase (PDH), thereby inhibiting the production of acetyl-CoA from pyruvate and redirecting it toward lactic acid production instead