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Additionally, current protocols predominantly rely on fresh plant materials, which imposes stringent requirements on harvesting, preservation, and storage conditions for maintaining PDEVs integrity and function

In obese individuals, elevated insulin levels in the fasting state and following protein intake may trigger oxidative stress-induced insulin resistance mediated by adipocyte-derived factors, including TNF-, leptin, and free fatty acids, which are early indicators of diabetes 49

Mild oxidative stress appears to provide selectivity for a specifically targeted molecule and may constitute a signaling mechanism even when an irreversible modification is produced [69]