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In mammals, CI is the largest mitochondrial complex composed of 45 subunits, of which 7 are encoded by mitochondrial DNA, namely ND1, ND2, ND3, ND4, ND4L, ND5, and ND6, and the remaining 38 subunits are encoded by nuclear genes

It can cross the blood-brain barrier and directly influence the brains antioxidant and anti-inflammatory pathways, particularly through Nrf2 activation which protects neurons from oxidative stress a major contributor to neurodegenerative diseases like Alzheimers and Parkinsons

The findings indicate that curcumin has the capacity to regulate the function and expression of these transportation proteins, hence playing a key role in counteracting MDR of cancer cells

From selenium to selenoproteins: synthesis, identity, and their role in human health

At the same time, the bodys natural antioxidant enzymes, such as catalase and superoxide dismutase, are also damaged, which affects tyrosinase and sharply reduces its activity

J Clin Oncol 21(23):4407-12, 2003