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& Doll, M

In adipose and ovarian tissues, macrophages are abnormally activated and polarized toward a pro-inflammatory (M1) phenotype, secreting IL-6, TNF-, and other factors that exacerbate local and systemic inflammation and insulin resistance, potentially interfering with follicular development (18)

MDR, multidrug-resistant organism

Erinacine C was mostly evaluated in vitro , with only two of the seven papers featuring in vivo experiments

67 (5 Suppl

In particular, bacterial species can contribute either directly or indirectly to cancer initiation and/or progression, by mechanisms ranging from the production of toxins and dietary metabolites to biofilm formation and inhibition of anti-tumoral immune responses [64]